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Trocer 400mcg Spray
Glyceryl Trinitrate (Nitroglycerin)/Trocer sublingual spray is an effective, rapid-acting treatment for angina pectoris.
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✅ Description:
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Trocer sublingual spray is used for:
- Acute relief of an angina attack.
- Prophylaxis of angina pectoris due to coronary artery disease.
✔️ Side Effects
Common: Headache, facial flushing, dizziness, nausea, vomiting, weakness, postural hypotension, reflex tachycardia.
✔️ Pharmacology:
- Primary Action: Relaxes vascular smooth muscles.
- Effects:
- Veins: Promotes blood pooling, decreases venous return to the heart, and reduces preload.
- Arteries: Reduces systemic vascular resistance and arterial pressure, lowering afterload.
- Outcome: Relieves the workload on the heart and improves oxygen delivery.
✔️ Dosage & Administration:
At Onset of Angina:
- Administer 1 or 2 sprays under the tongue.
- Maximum: 3 sprays within 15 minutes.
- If chest pain persists, seek immediate medical attention.
Prophylactic Use:
- Spray 5-10 minutes before engaging in activities that may trigger an attack.
✔️ Special Instructions for Use:
- Sit down as soon as angina symptoms begin.
- Remove the plastic cap without shaking the container.
- Hold the container upright with the forefinger on the button.
- Open the mouth and aim the nozzle under the tongue.
- Press the button slowly to spray.
- Avoid swallowing immediately after spraying. Do not drink water for 5-10 minutes.
✔️ Interactions:
- Alcohol: This may cause severe hypotension and collapse.
- Medications:
- May enhance dihydroergotamine bioavailability.
- Risk of orthostatic hypotension with calcium channel blockers, phenothiazines, and tricyclic antidepressants.
- Avoid concurrent use with sildenafil, vardenafil, or tadalafil due to the risk of severe hypotension, heart attack, or death.
✔️ Overdose Effects:
- Symptoms: Severe hypotension, headache, vertigo, visual disturbance, flushing, nausea, vomiting, cyanosis (methemoglobinemia), syncope, confusion, convulsions, and potentially fatal circulatory collapse.
- Treatment:
- Keep the patient in a shock position and warm.
- Administer oxygen and ventilatory support as needed.
- Methemoglobinemia: Treat with intravenous methylene blue (1-2 mg/kg).
- If ingested, gastric lavage may be useful.
✔️ Contraindications:
- Hypersensitivity to nitrates or formulation components.
- Conditions including:
- Severe hypotension, hypovolemia, or anemia.
- Cerebral hemorrhage or brain trauma.
- Mitral stenosis or hypertrophic obstructive cardiomyopathy.
✔️ Pregnancy & Lactation:
- Pregnancy: Category C. Use only if needed.
- Lactation: Unknown if excreted in breast milk; use with caution.
✔️ Precautions & Warnings:
- Monitor hemodynamics and clinical status during early days of acute myocardial infarction.
- Use cautiously in patients with:
- Impaired renal or hepatic function.
- Hypothyroidism, malnutrition, or hypothermia.
- Pediatrics: Safety and efficacy not established.
✔️ Storage Conditions:
- Store in a cool, dry place away from light and heat.
- Keep out of the reach of children.
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